منابع مشابه
Galanin overexpressing transgenic mice.
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT). Performance deficits on learning and memory tasks, impaired long-term potentiation, reduced hippocampal excitability, lower evoke...
متن کاملDeficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice.
Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety of spatial and aversive learning and memory tasks. The experiments in this study investigated the role galanin has in emotional learning and memory using a standard delay cued and contextual fear conditioning task. Rats were administered galanin into the lateral ventricles before training, a...
متن کاملCharacterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice
The neuropeptide galanin is widely expressed in both the central and peripheral nervous systems and is involved in many diverse biological functions. There is a substantial data set that demonstrates galanin is upregulated after injury in the DRG, spinal cord and in many brain regions where it plays a predominantly antinociceptive role in addition to being neuroprotective and pro-regenerative. ...
متن کاملmpaired relaxation in transgenic mice overexpressing junctin
Objective: Junctin is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum, which forms a quaternary complex 21 with the ryanodine receptor (Ca release channel), triadin, and calsequestrin. Methods: To better understand the role of junctin in excitation–contraction coupling in the heart, we generated transgenic mice with targeted overexpression of junctin to mouse heart, u...
متن کاملCraniosynostosis in transgenic mice overexpressing Nell-1.
Previously, we reported NELL-1 as a novel molecule overexpressed during premature cranial suture closure in patients with craniosynostosis (CS), one of the most common congenital craniofacial deformities. Here we describe the creation and analysis of transgenic mice overexpressing Nell-1. Nell-1 transgenic animals exhibited CS-like phenotypes that ranged from simple to compound synostoses. Hist...
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ژورنال
عنوان ژورنال: Neuropeptides
سال: 2002
ISSN: 0143-4179
DOI: 10.1054/npep.2002.0891